River Infection
The River Infection is the concept that, the more services and games that are created by River or use River systems, the larger and more powerful River Games will become.
Lore
"You single-handedly can't stop the River Infection." - SAM 2025[1]
The River Infection doesn't take a physical form. It is a creation of the River Games employees' greed for power.
Characters SAM like to acknowledge the River Infection, and seem to know what it is.
Citations
The grue was here